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typical antipsychotics  (Wolters Kluwer Health)

 
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    Wolters Kluwer Health typical antipsychotics
    Typical Antipsychotics, supplied by Wolters Kluwer Health, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Article Title: Abnormal correlation between serum leptin levels and body mass index may predict metabolic dysfunction irrespective of the psychopharmacological treatment
    Article Snippet: In an earlier study, we found a similar frequency of individuals with an abnormal correlation between serum leptin levels and body mass index (BMI) (outliers above or below the 95% confidence interval in the regression line) during treatment with antipsychotic drugs (n = 301), other psychotropic drugs (n = 65), and drug-free individuals (n = 229).. In this secondary analysis, we compare the frequency of the metabolic syndrome (International Diabetes Federation), its constituting variables, obesity, (BMI > 30 kg/m), leptin and insulin serum levels, and an insulin-resistance index (homeostatic model assessment-insulin resistance) in outliers, nonoutliers distributed in their original treatment groups, and all the nonoutliers controlled by age, sex, and BMI.. We identified 28 outliers, 24 above and four below the 95% confidence interval limits.



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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the CLP test measured with a stopwatch (graphs B, D, and F). Graph A, haloperidol bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.

    Journal: Pharmacology, biochemistry, and behavior

    Article Title: Evaluation of the potential of antipsychotic agents to induce catalepsy in rats: assessment of a new, commercially available, semi-automated instrument.

    doi: 10.1016/j.pbb.2014.02.013

    Figure Lengend Snippet: Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the CLP test measured with a stopwatch (graphs B, D, and F). Graph A, haloperidol bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.

    Article Snippet: Contents lists available at ScienceDirect Pharmacology, Biochemistry and Behavior j ourna l homepage: www.e lsev ie r .com/ locate /pharmbiochembeh Evaluation of the potential of antipsychotic agents to induce catalepsy in rats: Assessment of a new, commercially available, semi-automated instrument Barbara Bricker, Dinithia Sampson, Seth Y. Ablordeppey Division of Basic Pharmaceutical Sciences, Florida A&M University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, FL 32307, USA http://dx.doi.org/10.1016/j.pbb.2014.02.013 0091-3057/Published by Elsevier Inc. a b s t r a c t a r t i c l e i n f o Article history: Received 12 August 2013 Received in revised form 7 January 2014 Accepted 16 February 2014 Available online 21 February 2014 Keywords: Catalepsy instrument Bar test for catalepsy Extrapyramidal side effect (EPS) Crossed-leg position (CLP) test Typical antipsychotics Atypical antipsychotics Haloperidol induced catalepsy was determined using the classic bar test and a new MED Associates Catalepsy Test Chamber instrument.

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